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The Rosie Effect is the sequel to Graeme Simsion's bestselling novel The Rosie Project. The story picks up with Don Tillman and Rosie Jarman now married and living in New York City. Don, a genetics professor with Asperger's syndrome, faces the challenges of impending fatherhood and the complexities of married life. As Rosie becomes pregnant, Don's well-intentioned but often misguided attempts to prepare for fatherhood lead to humorous and poignant situations. The novel explores themes of love, family, and the nuances of relationships, all through Don's unique perspective.